Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J Exp Med. 2015 Mar 9;212(3):287-95. Epub 2015 Mar 2 PubMed.

Recommends

Please login to recommend the paper.

Comments

No Available Comments

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

Research Models

  1. Trem2 KO (KOMP) x APPPS1
  2. Trem2 KO (KOMP) x htau
  3. Trem2 R47H KI (Lamb/Landreth) X APPPS1-21

News

  1. Microglia—Who Are You Really? New Clues Emerge
  2. Alzheimer’s Risk Genes Interact in Immune Cells
  3. Unbiased Screen Fingers TREM2 Ligands That Promote Aβ Uptake
  4. ApoE and Trem2 Flip a Microglial Switch in Neurodegenerative Disease
  5. Boost or Block TREM2? Either Way, Therapy May Need Careful Timing