Hampel H, Buerger K, Kohnken R, Teipel SJ, Zinkowski R, Moeller HJ, Rapoport SI, Davies P. Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol. 2001 Apr;49(4):545-6. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
tau-p231
(CSF)		 AD
(17)		 53.3 ± 25.5
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
tau-p231
(CSF)		 CTRL-
CNC
(12)		 2.2 ± 11.7
pg/mL		 ELISA;
Other/Not Specified;
In-house
tau-total
(CSF)		 AD
(17)		 496.2 ± 204.6
pg/mL		 ELISA;
Innotest;
Innogenetics		 McKhann et al., 1984
tau-total
(CSF)		 CTRL-
CNC
(12)		 312.2 ± 98.2
pg/mL		 ELISA;
Innotest;
Innogenetics

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AlzBiomarker

  1. AD vs CTRL : tau-p231 (CSF)
  2. CTRL vs AD : tau-p231 (CSF)
  3. AD vs CTRL : tau-total (CSF)
  4. CTRL vs AD : tau-total (CSF)