This paper mixes well with the dynamitin paper that was published some time back. Also, its chaperone function is definitely interesting. The only other chaperones studied in ALS are HSP70 and CCS. However, no mutations in any chaperones have been identified before. The HSP70 knockout and the CCS knockout mice also showed no change in phenotype when crossed to the SOD1 mice.
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Ohio State University
This paper mixes well with the dynamitin paper that was published some time back. Also, its chaperone function is definitely interesting. The only other chaperones studied in ALS are HSP70 and CCS. However, no mutations in any chaperones have been identified before. The HSP70 knockout and the CCS knockout mice also showed no change in phenotype when crossed to the SOD1 mice.
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