Paper
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Blennow K, Wallin A, Agren H, Spenger C, Siegfried J, Vanmechelen E. Tau protein in cerebrospinal fluid: a biochemical marker for axonal degeneration in Alzheimer disease?. Mol Chem Neuropathol. 1995 Dec;26(3):231-45. PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : albumin ratio (CSF)
- CTRL vs AD : albumin ratio (CSF)
- FTD vs AD : albumin ratio (CSF)
- VaD vs AD : albumin ratio (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- DEP vs AD : tau-total (CSF)
- FTD vs AD : tau-total (CSF)
- PD vs AD : tau-total (CSF)
- VaD vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| albumin ratio (CSF/Blood) |
AD (44) |
7.3 ± 3.5 mg/L:g/L |
Nephelometry; Other/Not Specified; Other/Not Specified |
McKhann et al., 1984 |
| albumin ratio (CSF/Blood) |
CTRL- CNC (31) |
5.3 ± 1.7 mg/L:g/L |
Nephelometry; Other/Not Specified; Other/Not Specified |
|
| albumin ratio (CSF/Blood) |
FTD (11) |
6.8 ± 1.8 mg/L:g/L |
Nephelometry; Other/Not Specified; Other/Not Specified |
|
| albumin ratio (CSF/Blood) |
VaD (17) |
8.3 ± 4 mg/L:g/L |
Nephelometry; Other/Not Specified; Other/Not Specified |
|
| tau-total (CSF) |
AD (44) |
524 ± 280 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (31) |
185 ± 50 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
DEP (10) |
108 ± 13 pg/mL |
ELISA; Innotest; Innogenetics |
1986 |
| tau-total (CSF) |
FTD (11) |
275 ± 131 pg/mL |
ELISA; Innotest; Innogenetics |
|
| tau-total (CSF) |
PD (15) |
216 ± 105 pg/mL |
ELISA; Innotest; Innogenetics |
Langston et al., 1992 |
| tau-total (CSF) |
VaD (17) |
445 ± 195 pg/mL |
ELISA; Innotest; Innogenetics |
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