Krylova SM, Musheev M, Nutiu R, Li Y, Lee G, Krylov SN. Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures. FEBS Lett. 2005 Feb 28;579(6):1371-5. PubMed.

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  1. New methodology provides evidence that tau binds to single stranded DNA as well as to dsDNA. With a limited range of oligonucleotides, there was evidence of sequence specificity in the binding of ssDNA. The authors speculate that tau may have a role in chromatin activation.

    View all comments by George Martin

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