Alvarez A, Alarcón R, Opazo C, Campos EO, Muñoz FJ, Calderón FH, Dajas F, Gentry MK, Doctor BP, de Mello FG, Inestrosa NC. Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils. J Neurosci. 1998 May 1;18(9):3213-23. PubMed.
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Alvarez et al report that acetylcholinesterase (ACHE) forms stable complexes with amyuloid-beta and that this transforms the chemical properties of ACHE and increases the neurotoxicity of amyloid beta aggregates. This is interesting but it is difficult to evaluate, based on the information in the abstract, because no information is given regarding how the neurotoxicity tests were performed. Presumably all of the work was performed in cell cultures. A major weakness of the study is that, even if everything reported is true, it does not establish a link between the ACHE/amyloid complex and neurodegeneration in AD.
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