Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M.
Secretion of the Notch-1 Abeta-like peptide during Notch signaling.
J Biol Chem. 2006 Mar 24;281(12):7890-8.
PubMed.
Presenilin cleaves both APP and Notch, but the corresponding Nbeta peptide has never been identified. This manuscript shows a striking concordance between Notch processing and APP processing and identifies the long sought-after Nbeta peptide. Very interesting.
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Boston University School of Medicine
Presenilin cleaves both APP and Notch, but the corresponding Nbeta peptide has never been identified. This manuscript shows a striking concordance between Notch processing and APP processing and identifies the long sought-after Nbeta peptide. Very interesting.
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