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Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem. 2001 Oct 12;276(41):38193-200. Epub 2001 Jul 25 PubMed.
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Kins et al, have done an important study on a rather neglected aspect of AD pathology, ie, the role of protein phosphatases. Their transgenic mouse model with reduced phosphatase 2A activity will be quite useful not only for further studies of tau phosphorylation, but also for the study of other neuronal phosphoproteins, protein kinases, and their involvement in neurodegenerative diseases.
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