Hu WT, Watts K, Grossman M, Glass J, Lah JJ, Hales C, Shelnutt M, Van Deerlin V, Trojanowski JQ, Levey AI. Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP. Neurology. 2013 Nov 26;81(22):1945-52. Epub 2013 Oct 30 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : tau-p181 (CSF)
- CTRL vs AD : tau-p181 (CSF)
- FTD vs AD : tau-p181 (CSF)
- AD vs CTRL : tau-total (CSF)
- CTRL vs AD : tau-total (CSF)
- FTD vs AD : tau-total (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| tau-p181 (CSF) |
AD (25) |
66.2 ± 45.1 pg/mL |
xMAP; AlzBio3; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
CTRL- CNC (13) |
35.5 ± 18.3 pg/mL |
xMAP; AlzBio3; Innogenetics |
|
| tau-p181 (CSF) |
FTD- FTLD-TDP43 (33) |
15.7 ± 6.9 pg/mL |
xMAP; AlzBio3; Innogenetics |
Neary et al., 1998; Grossman, 2010 |
| tau-p181 (CSF) |
FTD- FTLD-Tau (20) |
20.3 ± 7 pg/mL |
xMAP; AlzBio3; Innogenetics |
Neary et al., 1998; Grossman, 2010 |
| tau-total (CSF) |
AD (25) |
116.4 ± 72 pg/mL |
xMAP; AlzBio3; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
CTRL- CNC (13) |
49.2 ± 24.4 pg/mL |
xMAP; AlzBio3; Innogenetics |
|
| tau-total (CSF) |
FTD- FTLD-TDP43 (33) |
53.2 ± 22.1 pg/mL |
xMAP; AlzBio3; Innogenetics |
Neary et al., 1998; Grossman, 2010 |
| tau-total (CSF) |
FTD- FTLD-Tau (20) |
52.3 ± 23.4 pg/mL |
xMAP; AlzBio3; Innogenetics |
Neary et al., 1998; Grossman, 2010 |
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