Klein RC, Mace BE, Moore SD, Sullivan PM. Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2. Neuroscience. 2010 Dec 29;171(4):1265-72. Epub 2010 Oct 15 PubMed.

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Research Models

  1. APOE3 Targeted Replacement

Mutations

  1. APOE [R176C];[C130R] (ApoE2/4)