Grilli M, Diodato E, Lozza G, Brusa R, Casarini M, Uberti D, Rozmahel R, Westaway D, St George-Hyslop P, Memo M, Ongini E. Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12822-7. PubMed.
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Columbia University
This is an important study offering new insights to the mechanisms by with genetic mutations alter the function of proteins such as Presenilin.
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