Tokuhiro S, Tomita T, Iwata H, Kosaka T, Saido TC, Maruyama K, Iwatsubo T. The presenilin 1 mutation (M146V) linked to familial Alzheimer's disease attenuates the neuronal differentiation of NTera 2 cells. Biochem Biophys Res Commun. 1998 Mar 27;244(3):751-5. PubMed.
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Osaka City University Medical School
PS-1 is claimed to play a role in neuronal differentiation. It may explain some of disoprders seen in PS-1 knock-out mice.
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