Klementieva O, Willén K, Martinsson I, Israelsson B, Engdahl A, Cladera J, Uvdal P, Gouras GK. Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP. Nat Commun. 2017 Mar 13;8:14726. PubMed.

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  1. By elegantly combining biophysics and in vivo structural biology, the authors identify the possible existence of tetrameric Aβ and the conformational change before plaque deposition occurs. This could suggest that, like transthyretin and the infamous α-synuclein, we might need to be looking at tetramers as a “prepathological form,” and we might need to brace ourselves for the fact that stabilizing tetrameric Aβ could be a possibility for therapy. Aβ-APP binding and a possible influence on the subsequent APP processing are also potential avenues for therapy. Gunnar Gouras is arguably one of the fine minds in the AD field, and his latest work gives new insights and makes us rethink our therapeutic deliberations for AD.

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