Hamdane M, Dourlen P, Bretteville A, Sambo AV, Ferreira S, Ando K, Kerdraon O, Bégard S, Geay L, Lippens G, Sergeant N, Delacourte A, Maurage CA, Galas MC, Buée L. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60. Epub 2006 May 11 PubMed.

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    • User Profile Image Luc Buee
      Lille Neuroscience & Cognition
    • Posted:

    Pin1 was always considered a cell cycle regulator. This article indicates that Pin1 is likely a key actor in neurons. In fact, there is an up-regulation of Pin1 during neuronal differentiation and a specific tau dephosphorylation on Thr231.

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Therapeutics

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