Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E.
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.
EMBO J. 2011 Nov 30;30(23):4825-37.
PubMed.
The localization data generated with Dendra2 are fascinating. It could be interesting to use the experiment to corroborate the postulate from Hoover et al. that pathological tau is relocalized (accumulated in) to dendrites.
References:
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D.
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration.
Neuron. 2010 Dec 22;68(6):1067-81.
PubMed.
Comments
RIKEN Center for Brain Science
An important paper.
Neuroscientist, CSO Bright Minds Bioscience Inc.
The localization data generated with Dendra2 are fascinating. It could be interesting to use the experiment to corroborate the postulate from Hoover et al. that pathological tau is relocalized (accumulated in) to dendrites.
References:
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan LL, Ashe KH, Liao D. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 2010 Dec 22;68(6):1067-81. PubMed.
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