Teunissen CE, Elias N, Koel-Simmelink MJ, Durieux-Lu S, Malekzadeh A, Pham TV, Piersma SR, Beccari T, Meeter LH, Dopper EG, van Swieten JC, Jimenez CR, Pijnenburg YA. Novel diagnostic cerebrospinal fluid biomarkers for pathologic subtypes of frontotemporal dementia identified by proteomics. Alzheimers Dement (Amst). 2016;2:86-94. Epub 2016 Jan 19 PubMed.
AlzBiomarker Database
Meta-Analysis
- AD vs CTRL : YKL-40 (CSF)
- CTRL vs AD : YKL-40 (CSF)
- DLB vs AD : YKL-40 (CSF)
- FTD vs AD : YKL-40 (CSF)
- VaD vs AD : YKL-40 (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| YKL-40 (CSF) |
AD (20) |
277.625 ± 952.891 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
McKhann et al., 2011; McKhann et al., 1984 |
| YKL-40 (CSF) |
CTRL- CNC (23) |
211.655 ± 855.539 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
|
| YKL-40 (CSF) |
DLB (20) |
236.845 ± 752.277 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
McKeith et al., 2005 |
| YKL-40 (CSF) |
FTD- FTLD-TDP43 (20) |
323.039 ± 1176.06 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
Rascovsky et al., 2011 |
| YKL-40 (CSF) |
FTD- FTLD-Tau (10) |
378.514 ± 901.3 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
Rascovsky et al., 2011 |
| YKL-40 (CSF) |
VaD (18) |
263.289 ± 962.299 ng/mL § |
ELISA; Other/Not Specified; Quidel Corporation |
Román et al., 1993 |
§ Data supplied to Alzforum by author
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