Nishimoto I.
A new paradigm for neurotoxicity by FAD mutants of betaAPP: a signaling abnormality.
Neurobiol Aging. 1998 Jan-Feb;19(1 Suppl):S33-8.
PubMed.
Nishimoto reviews a hypothesis generated by his group pertaining to beta APP as a signaling receptor molecule which is activated by point mutations. They state that the presence of such mutations cause neuronal cells to undergo apoptotic death by a G protein-mediated mechanism and this can explain the neuropathology of AD. In this abstract, the authors do not state what kind of model systems and methods they have used to demonstrate how point mutations cause apoptotic cell death and how all of this relates to AD. However, it is an unfortunate fact that most of the claims being made about apoptotic cell death in AD are bogus claims based on inappropriate methods that are being used to diagnose apoptosis. Therefore, I am reluctant to accept their "novel insights" about the role of beta APP as a death receptor that mediates neuronal suicide in AD.
His hypothesis that G protein is tightly associated with AD degeneration is very unique and interesting on the viewpoint of signal transduction disorder.
Comments
Nishimoto reviews a hypothesis generated by his group pertaining to beta APP as a signaling receptor molecule which is activated by point mutations. They state that the presence of such mutations cause neuronal cells to undergo apoptotic death by a G protein-mediated mechanism and this can explain the neuropathology of AD. In this abstract, the authors do not state what kind of model systems and methods they have used to demonstrate how point mutations cause apoptotic cell death and how all of this relates to AD. However, it is an unfortunate fact that most of the claims being made about apoptotic cell death in AD are bogus claims based on inappropriate methods that are being used to diagnose apoptosis. Therefore, I am reluctant to accept their "novel insights" about the role of beta APP as a death receptor that mediates neuronal suicide in AD.
Osaka City University Medical School
His hypothesis that G protein is tightly associated with AD degeneration is very unique and interesting on the viewpoint of signal transduction disorder.
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