Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):13990-5. PubMed.

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- Edward Koo
- Posted: 21 Oct 2002
Elegant study although I still wonder why it is so hard to kill neurons in rodent brain. It just seems curious to me that it takes that much effort to document neuronal loss. Also, when the amyloid deposits are that aggregated, is it "toxicity" or just mechanical, i.e. a big blob sitting in the middle of the brain eventually kills the nearby neurons.

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