Rosengren LE, Karlsson JE, Sjögren M, Blennow K, Wallin A. Neurofilament protein levels in CSF are increased in dementia. Neurology. 1999 Mar 23;52(5):1090-3. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
NFL
(CSF)		 AD
(37)		 348 ± 216
pg/mL		 ELISA;
Other/Not Specified;
In-house		 McKhann et al., 1984
NFL
(CSF)		 CTRL-
CNC
(39)		 156 ± 80
pg/mL		 ELISA;
Other/Not Specified;
In-house
NFL
(CSF)		 VaD
(20)		 674 ± 578
pg/mL		 ELISA;
Other/Not Specified;
In-house		 Román et al., 1993
albumin ratio
(CSF/Blood)		 AD
(37)		 6.3 ± 2.3
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
In-house		 McKhann et al., 1984
albumin ratio
(CSF/Blood)		 CTRL-
CNC
(39)		 5.7 ± 2.1
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
In-house
albumin ratio
(CSF/Blood)		 VaD
(20)		 7.6 ± 3
(CSF mg/L)/(Serum g/L)		 Nephelometry;
Other/Not Specified;
In-house		 Román et al., 1993

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Comments

  1. But these levels apparently do not differentiate vascular dementia, FTD and AD.

    View all comments by Paul Coleman

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This paper appears in the following:

AlzBiomarker

  1. AD vs CTRL : NFL (CSF)
  2. CTRL vs AD : NFL (CSF)
  3. VaD vs AD : NFL (CSF)
  4. AD vs CTRL : albumin ratio (CSF)
  5. CTRL vs AD : albumin ratio (CSF)
  6. VaD vs AD : albumin ratio (CSF)