Paloneva J, Manninen T, Christman G, Hovanes K, Mandelin J, Adolfsson R, Bianchin M, Bird T, Miranda R, Salmaggi A, Tranebjaerg L, Konttinen Y, Peltonen L. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet. 2002 Sep;71(3):656-62. Epub 2002 Jun 21 PubMed.

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Mutations

  1. TREM2 K186N
  2. TREM2 D134G
  3. TREM2 c.482+2T>C
  4. TREM2 W44Ter
  5. TREM2 W78Ter

News

  1. Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
  2. Mutations in Microglia Protein Cause Rare Dementia
  3. Fall Flurry of Letters Kicks Up Dust Around TREM2
  4. A New Link Between Alzheimer’s and Nasu-Hakola Disease?
  5. In Nasu-Hakola Disease, DAP12-Deficient Microglia Kick Repair into Overdrive

Research Models

  1. Trem2 KO (JAX)
  2. Trem2 KO (KOMP) x APPPS1
  3. Trem2 KO (KOMP)
  4. Trem2 KO (KOMP) x htau
  5. Trem2 KO (Colonna)
  6. Trem2 KO (Colonna) x 5XFAD
  7. Trem2 KO (Colonna) x PS19
  8. TREM2-BAC
  9. TREM2-BAC X 5xFAD