Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, Beletchi I, Verstraeten A, Gossye H, Gelders G, Pals P, Hamouda NN, Engelborghs S, Martin JJ, Eggermont J, De Deyn PP, Cras P, Baekelandt V, Vangheluwe P, Van Broeckhoven C, BELNEU consortium. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020 Jun;139(6):1001-1024. Epub 2020 Mar 14 PubMed.
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Northwestern University
This is an interesting study that highlights the importance of lysosomal function and lipid homeostasis in synucleinopathies. The findings also suggest a converging mechanism between mutations in ATP10B and GBA1 via accumulation of glucosylceramide.
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