It is well established that chaperone proteins are involved in assisting all but the smallest proteins to fold properly during protein biosynthesis. It is not unreasonable to suspect that abnormal chaperone functions might also play a role in diseases involving protein misfolding. These authors describe the use of an isoprenoid called geranylgeranylacetone (GGA) which they believe is a non-toxic Hsp70 inducer, and they describe how this compound appears to block insult-induced apoptosis. It may be worth using their approach to try to moderate CNS damage under different experimental situations.
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Yale University School of Medicine
It is well established that chaperone proteins are involved in assisting all but the smallest proteins to fold properly during protein biosynthesis. It is not unreasonable to suspect that abnormal chaperone functions might also play a role in diseases involving protein misfolding. These authors describe the use of an isoprenoid called geranylgeranylacetone (GGA) which they believe is a non-toxic Hsp70 inducer, and they describe how this compound appears to block insult-induced apoptosis. It may be worth using their approach to try to moderate CNS damage under different experimental situations.
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