Chrétien D, Bénit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs HT, Rustin P, Rak M. Mitochondria are physiologically maintained at close to 50 °C. PLoS Biol. 2018 Jan;16(1):e2003992. Epub 2018 Jan 25 PubMed.
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University of Kansas
This is an interesting observation and the thermos-sensitive fluorescent probe may become a tool for observing mitochondrial function. Based on the results generated from in vitro human cell lines, it appears that mitochondrial respiratory function positively associates with in situ temperature. This needs to be validated by other methodologies independent of this Flu-probe and in multiple cells including primary neuronal cells, since neurons are most demanding for mitochondrial energy and ATP production. It could be more important to validate the physiological role of high temperature in in vivo models. Additionally, the biological significance from this study is unclear and requires further investigation.
Chemically, it is unclear what properties of this Flu-probe make it resistant to temperature and accurate for monitoring temperature in the in vivo setting and during pathophysiological conditions.
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