Martin N, Jaubert J, Gounon P, Salido E, Haase G, Szatanik M, Guénet JL. A missense mutation in Tbce causes progressive motor neuronopathy in mice. Nat Genet. 2002 Nov;32(3):443-7. PubMed.

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- Tennore Ramesh
  Ohio State University
- Posted: 28 Oct 2002
- News: Tubulin Chaperone Found to Cause Rare Motor Neuron Degeneration, and More
This paper mixes well with the dynamitin paper that was published some time back. Also, its chaperone function is definitely interesting. The only other chaperones studied in ALS are HSP70 and CCS. However, no mutations in any chaperones have been identified before. The HSP70 knockout and the CCS knockout mice also showed no change in phenotype when crossed to the SOD1 mice.

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