McNamara NB, Munro DA, Bestard-Cuche N, Uyeda A, Bogie JF, Hoffmann A, Holloway RK, Molina-Gonzalez I, Askew KE, Mitchell S, Mungall W, Dodds M, Dittmayer C, Moss J, Rose J, Szymkowiak S, Amann L, McColl BW, Prinz M, Spires-Jones TL, Stenzel W, Horsburgh K, Hendriks JJ, Pridans C, Muramatsu R, Williams A, Priller J, Miron VE. Microglia regulate central nervous system myelin growth and integrity. Nature. 2023 Jan;613(7942):120-129. Epub 2022 Dec 14 PubMed. Correction.

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  1. In AD and in vascular dementia, microglia also mop up myelin debris. Since this debris is high in iron content, the microglia are killed via ferroptosis (Adeniyi et al., 2023).

    References:

    Adeniyi PA, Gong X, MacGregor E, Degener-O'Brien K, McClendon E, Garcia M, Romero O, Russell J, Srivastava T, Miller J, Keene CD, Back SA. Ferroptosis of Microglia in Aging Human White Matter Injury. Ann Neurol. 2023 Dec;94(6):1048-1066. Epub 2023 Sep 14 PubMed.

    View all comments by Charles Stromeyer

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