Berghoff SA, Spieth L, Sun T, Hosang L, Schlaphoff L, Depp C, Düking T, Winchenbach J, Neuber J, Ewers D, Scholz P, van der Meer F, Cantuti-Castelvetri L, Sasmita AO, Meschkat M, Ruhwedel T, Möbius W, Sankowski R, Prinz M, Huitinga I, Sereda MW, Odoardi F, Ischebeck T, Simons M, Stadelmann-Nessler C, Edgar JM, Nave KA, Saher G. Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis. Nat Neurosci. 2021 Jan;24(1):47-60. Epub 2020 Dec 21 PubMed.

Comments

- Charles Stromeyer
- Posted: 22 Oct 2023
- News: Does the Brain Use Microglia to Maintain Its Myelin?
In AD and in vascular dementia, microglia also mop up myelin debris. Since this debris is high in iron content, the microglia are killed via ferroptosis (Adeniyi et al., 2023).

References:

Adeniyi PA, Gong X, MacGregor E, Degener-O'Brien K, McClendon E, Garcia M, Romero O, Russell J, Srivastava T, Miller J, Keene CD, Back SA. Ferroptosis of Microglia in Aging Human White Matter Injury. Ann Neurol. 2023 Dec;94(6):1048-1066. Epub 2023 Sep 14 PubMed.

View all comments by Charles Stromeyer

Make a Comment

To make a comment you must login or register.

Paper

Tools

Comments

References:

Make a Comment

This paper appears in the following:

News