A very interesting review on mitochondrial dysfunction and energy hypometabolism in AD, highlighting the interaction of cellular heme and Aβ. From our own proteomics and functional studies we have evidence for a mitochondrial dysfunction in tauopathies (David et al., 2005).
References:
David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Müller WE, Eckert A, Götz J.
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice.
J Biol Chem. 2005 Jun 24;280(25):23802-14.
PubMed.
Comments
The University of Queensland
A very interesting review on mitochondrial dysfunction and energy hypometabolism in AD, highlighting the interaction of cellular heme and Aβ. From our own proteomics and functional studies we have evidence for a mitochondrial dysfunction in tauopathies (David et al., 2005).
References:
David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Müller WE, Eckert A, Götz J. Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem. 2005 Jun 24;280(25):23802-14. PubMed.
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