Lamb J, Ramaswamy S, Ford HL, Contreras B, Martinez RV, Kittrell FS, Zahnow CA, Patterson N, Golub TR, Ewen ME.
A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.
Cell. 2003 Aug 8;114(3):323-34.
PubMed.
This paper is a nice illustration of how large, diverse data sets of high-quality microarray data can be mined for evidence to support novel hypotheses of gene function and regulation.
We have recently been performing similar studies of common gene expression patterns in peripheral blood and brain autopsy samples for several different nerurodegenerative disorders including Huntington's and Parkinson's disease. The key is high-quality samples and reliable microarray data. In these cases, we can even look for common patterns of coregulated genes measured using multiple microarray platforms, including the Amersham, Affymetrix and Agilent arrays. So far the preliminary results from these studies have been stunning.
All of this work is easily extended to Alzheimer's disease if large numbers of high quality samples can be run on reliable microarrays.
Comments
Wesleyan University
This paper is a nice illustration of how large, diverse data sets of high-quality microarray data can be mined for evidence to support novel hypotheses of gene function and regulation.
We have recently been performing similar studies of common gene expression patterns in peripheral blood and brain autopsy samples for several different nerurodegenerative disorders including Huntington's and Parkinson's disease. The key is high-quality samples and reliable microarray data. In these cases, we can even look for common patterns of coregulated genes measured using multiple microarray platforms, including the Amersham, Affymetrix and Agilent arrays. So far the preliminary results from these studies have been stunning.
All of this work is easily extended to Alzheimer's disease if large numbers of high quality samples can be run on reliable microarrays.
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