Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM. Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy. J Biol Chem. 2004 Dec 31;279(53):56004-13. PubMed.

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  1. We already know that another candidate enzyme for the in vivo degradation of Aβ plasmin is inhibited by aluminium (Al) (Korchazhkina et al., 2002). Perhaps Al might also inhibit IDE?

    References:

    Korchazhkina OV, Ashcroft AE, Kiss T, Exley C. The degradation of Abeta(25-35) by the serine protease plasmin is inhibited by aluminium. J Alzheimers Dis. 2002 Oct;4(5):357-67. PubMed.

    View all comments by Chris Exley

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  1. IDE—Levels Up, But Activity Down, in Amyloid-Burdened Vasculature