Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y.
Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex.
Neurology. 2005 Feb 22;64(4):687-92.
PubMed.
In a human brain one can see three main types of plaques: first Abeta 42 diffuse plaques, then amyloid plaques and at the end senile plaques also named neuritic plaques.
Senile plaques, with dystropic neurites filled with a tau pathology, represent the two degenerative processes that characterize AD. That is why they are so well correlated with the clinical stages of AD. To my knowledge, senile plaques are not observed at the first step of amyloidosis (observed in non-demented patients).
Mixing all these terminologies in the present paper is confusing. Also, trying to understand AD, a very complex disease, looking at only one brain area, is too restricted. If there is a synergy between tau and APP, as mentioned in our paper, one must look at the brain with a spatio-temporal approach.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP.
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
Neurology. 2002 Aug 13;59(3):398-407.
PubMed.
Comments
Inserm
In a human brain one can see three main types of plaques: first Abeta 42 diffuse plaques, then amyloid plaques and at the end senile plaques also named neuritic plaques.
Senile plaques, with dystropic neurites filled with a tau pathology, represent the two degenerative processes that characterize AD. That is why they are so well correlated with the clinical stages of AD. To my knowledge, senile plaques are not observed at the first step of amyloidosis (observed in non-demented patients).
Mixing all these terminologies in the present paper is confusing. Also, trying to understand AD, a very complex disease, looking at only one brain area, is too restricted. If there is a synergy between tau and APP, as mentioned in our paper, one must look at the brain with a spatio-temporal approach.
References:
Delacourte A, Sergeant N, Champain D, Wattez A, Maurage CA, Lebert F, Pasquier F, David JP. Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease. Neurology. 2002 Aug 13;59(3):398-407. PubMed.
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