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Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M. Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase. J Neurosci. 2014 May 7;34(19):6438-47. PubMed.
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Comments
The Florey Institute of Neuroscience
Our unpublished look at this interaction showed by SPR and NMR that recombinant DR6 associates with APP via the disordered stalk domain, rather than the globular cys-rich domain.
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