Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem. 2008 Jan 11;283(2):677-83. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. One wonders about the mechanism that is the basis for these interesting data.

    View all comments by Paul Coleman

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Keystone: Loss Versus Gain—Mutations a Drag on γ-Secretase
  2. Paris: Intracellular Traffic and Neurodegenerative Disorders

Mutations

  1. PSEN1 M146L (A>C)
  2. PSEN1 M146L (A>T)
  3. PSEN1 A285V