Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S.
Gene expression profiling in the adult Down syndrome brain.
Genomics. 2007 Dec;90(6):647-60.
PubMed.
An interesting transcriptomics study identifying differentially expressed genes and differentially regulated gene categories in Down Syndrome. Interestingly, although APP mRNA was not changed, some genes involved in APP processing (such as BACE2 and S100B; apolipoproteins APOE and CLU, plus PSEN1, PSEN2, and MAPT) were.
A number of the deregulated genes were also found to be differentially regulated at the proteome level when the new data were compared to previously published proteomics data by the same group.
Comments
The University of Queensland
An interesting transcriptomics study identifying differentially expressed genes and differentially regulated gene categories in Down Syndrome. Interestingly, although APP mRNA was not changed, some genes involved in APP processing (such as BACE2 and S100B; apolipoproteins APOE and CLU, plus PSEN1, PSEN2, and MAPT) were.
A number of the deregulated genes were also found to be differentially regulated at the proteome level when the new data were compared to previously published proteomics data by the same group.
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