Bateman RJ, Siemers ER, Mawuenyega KG, Wen G, Browning KR, Sigurdson WC, Yarasheski KE, Friedrich SW, Demattos RB, May PC, Paul SM, Holtzman DM. A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system. Ann Neurol. 2009 Jul;66(1):48-54. PubMed.

Recommends

Please login to recommend the paper.

Comments

  1. This paper nicely describes the use of an elegant method for assessing brain-relevant biomarkers of protein metabolism in humans.

    View all comments by Lary Walker

Make a Comment

To make a comment you must login or register.

This paper appears in the following:

News

  1. Studies Reveal New Hope, Old Problems With AD Biomarkers
  2. Honolulu: Wake-Up Call—Aβ Clearance, Not Production, Awry in AD
  3. Miami: Is Human Amyloid Imaging Ready for Clinical Trials?
  4. Research Brief: Can γ-secretase Inhibitor Treatment Stand Alone?
  5. Research Brief: APL1β28—Surrogate for CNS Aβ42 Production?
  6. Top AD Trends of 2009

Therapeutics

  1. Semagacestat

Research Timeline Event

  1. Live CSF monitoring shows Aβ clearance is reduced in LOAD