Tabner BJ, Turnbull S, El-Agnaf OM, Allsop D. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83. PubMed.
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Boston University School of Medicine
This is an interesting article becuase it provides a common mechanism of toxicity for many different aggregated proteins. The link between synuclein and iron is particularly interesting because we have shown that synuclein readily binds iron and forms aggregates when exposed to iron. Generation of hydrogen peroxide, and from there free radicals provides a solid putative mechanism explaining synuclein mediated toxicity, although other mechanisms, such as proteasomal inhibition, also likely contribute to synuclein mediated toxicity.
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