Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med. 2005 Jul;11(7):797-803. Epub 2005 Jun 19 PubMed.

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Comments

  1. This mouse model seems to be a powerful tool to study different issues, the relationship between AD and lipids included. I am only surprised that cholesterol keeps being labelled as a risk factor for AD, despite the fact that in light of numerous old and particularly recent reports, this is completely unjustified. I would say that the concept about a positive relationship between AD and cholesterol should be announced as dead.

    References:

    Bohr IJ. Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease?. Lipids Health Dis. 2005;4:13. PubMed.

    Wood WG, Igbavboa U, Eckert GP, Johnson-Anuna LN, Müller WE. Is hypercholesterolemia a risk factor for Alzheimer's disease?. Mol Neurobiol. 2005;31(1-3):185-92. PubMed.

    View all comments by Iwo Bohr

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