Zetterberg H, Andreasson U, Hansson O, Wu G, Sankaranarayanan S, Andersson ME, Buchhave P, Londos E, Umek RM, Minthon L, Simon AJ, Blennow K. Elevated cerebrospinal fluid BACE1 activity in incipient Alzheimer disease. Arch Neurol. 2008 Aug;65(8):1102-7. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
Aβ40
(CSF)		 AD
(87)		 4927 ± 1217
pg/mL §		 Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery		 McKhann et al., 1984
Aβ40
(CSF)		 CTRL-
CNC
(33)		 5307 ± 1080
pg/mL §		 Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery
Aβ40
(CSF)		 MCI-AD
(45)		 4464 ± 1541
pg/mL §		 Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery		 McKhann et al., 1984
Aβ40
(CSF)		 MCI-Stable
(52)		 4949 ± 1192
pg/mL §		 Electrochemiluminescence;
MSD 6E10;
Meso Scale Discovery		 Petersen, 2004
sAPPα
(CSF)		 AD
(87)		 653 ± 252
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 McKhann et al., 1984
sAPPα
(CSF)		 CTRL-
CNC
(33)		 538 ± 223
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
sAPPα
(CSF)		 MCI-AD
(45)		 751 ± 383
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 McKhann et al., 1984
sAPPα
(CSF)		 MCI-Stable
(52)		 772 ± 276
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 Petersen, 2004
sAPPβ
(CSF)		 AD
(87)		 399 ± 140
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 McKhann et al., 1984
sAPPβ
(CSF)		 CTRL-
CNC
(33)		 369 ± 117
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery
sAPPβ
(CSF)		 MCI-AD
(45)		 435 ± 201
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 McKhann et al., 1984
sAPPβ
(CSF)		 MCI-Stable
(52)		 487 ± 178
ng/mL §		 Electrochemiluminescence;
Other/Not Specified;
Meso Scale Discovery		 Petersen, 2004

§ Data supplied to Alzforum by author

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This paper appears in the following:

News

  1. BACE1 Gets Attention as Potential Alzheimer’s Biomarker

AlzBiomarker

  1. AD vs CTRL : Aβ40 (CSF)
  2. CTRL vs AD : Aβ40 (CSF)
  3. MCI-AD vs MCI-Stable : Aβ40 (CSF)
  4. AD vs CTRL : sAPPα (CSF)
  5. CTRL vs AD : sAPPα (CSF)
  6. MCI-AD vs MCI-Stable : sAPPα (CSF)
  7. AD vs CTRL : sAPPβ (CSF)
  8. CTRL vs AD : sAPPβ (CSF)
  9. MCI-AD vs MCI-Stable : sAPPβ (CSF)