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Shenk JC, Liu J, Fischbach K, Xu K, Puchowicz M, Obrenovich ME, Gasimov E, Alvarez LM, Ames BN, Lamanna JC, Aliev G. The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease. J Neurol Sci. 2009 Aug 15;283(1-2):199-206. PubMed.
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University of Kansas
This paper advances what is known about the ApoE-mitochondria nexus. It provides mechanistic insights potentially relevant to Alzheimer disease. It is worth the read.
Missouri University of Science and Technology
The authors in this paper show that acetyl-L-carnitine and R-α-lipoic acids serve as effective antioxidants that potentially reverse the human ApoE4 allele induced age-dependent pathology in AD and other age-related diseases. ApoE4 transgenic mice closely resemble AD cases, and by comparing cerebral blood flow in wild-type and ApoE4 transgenic mice, the authors clearly paved the way for developing potential therapeutics for ApoE4 allele-related AD.
Medical University
This paper provides a new view that is potentially relevant to Alzheimer disease pathogenesis. It is very interesting.
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