Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb;121(2):726-38. Epub 2011 Jan 4 PubMed.
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University of California, San Diego
Wonderful, rigorous study, and perhaps a window into the future of neurodegeneration research. Though the thought is slightly disturbing, it is becoming more and more apparent that the aggregates, plaques, and tangles that we neuropathologists love to see (and preach about) may not be as important as we thought.
Genentech, Inc.
Thank you for this well-written article.
I would like to add this recent study, which showed that nucleic acid binding activity is required for TDP-43-mediated toxicity in flies.
C-terminal fragments of TDP-43 lack such activity, but are still capable of forming aggregates. This supports the hypothesis that the aggregates themselves are not toxic, and that instead, the toxicity is related to a modulation of the endogenous function of this nucleic acid binding protein.
Therefore, studies addressing its DNA and RNA targets may be very important in understanding TDP-43-mediated neurodegeneration.
References:
Voigt A, Herholz D, Fiesel FC, Kaur K, Müller D, Karsten P, Weber SS, Kahle PJ, Marquardt T, Schulz JB. TDP-43-mediated neuron loss in vivo requires RNA-binding activity. PLoS One. 2010;5(8):e12247. PubMed.
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