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Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N, Ashe KH, Frautschy SA, Cole GM. Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron. 2004 Sep 2;43(5):633-45. PubMed.
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With regard to the recent focus upon a diet rich in fish and its protective effect against Alzheimer's disease, please allow me to point out that the assumption that this is attributable to omega-3 fatty acids may be misguided.
There are two groups of foods that provide unusually high levels of silicic acid. Thin-skinned fruits such as grapes and blueberries evaporate moisture through the epidermous, thereby concentrating the solubilized silicon within the fruit.
And over the eons silicic acid endlessly concentrates in the oceans in the same manner as salt.
Thus, the two food groups from which consumers can expect to elevate their blood levels of silicic acid are thin-skinned fruit and marine seafood. And the two foods for which epidemiological studies have indicated a protective effect against Alzheimer's disease are red wine and fish.
View all comments by Colin MeyerDoes this study support a dissociation between LTP and spatial memory?
Itokazu and colleagues (1) report that DHA inhibits the induction of long-term potentiation in the CA1 area in rats, as is shown to be the case for Aβ in many studies.
I'd also be interested in the answer to the question proposed by Lennart Mucke and Robert Pitas as to whether production of Aβ is affected by DHA.
References:
Itokazu N, Ikegaya Y, Nishikawa M, Matsuki N. Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. Brain Res. 2000 Apr 17;862(1-2):211-6. PubMed.
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