Schilling S, Pradhan A, Heesch A, Helbig A, Blennow K, Koch C, Bertgen L, Koo EH, Brinkmalm G, Zetterberg H, Kins S, Eggert S. Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity. Acta Neuropathol Commun. 2023 Jun 1;11(1):87. PubMed.

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Mutations

  1. APP A692G (Flemish)
  2. APP E693G (Arctic)
  3. APP D694N (Iowa)
  4. APP I716F (Iberian)
  5. APP K670_M671delinsNL (Swedish)