Hallows JL, Chen K, DePinho RA, Vincent I. Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci. 2003 Nov 19;23(33):10633-44. PubMed.

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  1. I have just read this JN paper on cdk5 regulation and I found it to be one of the best papers on this issue out there. I truly want to express my satisfaction for describing phenomena many others have overseen just for the fact of being in agreement with the view of the well-known people in the field. This data helps explain lots of apparent contradictions, as it shows CDK5 and GSK3 work at the opposites sites of a theoretical balance.
    We have also observed some of the increases in phosphorylation of tau described in this work and I express my satisfaction for such an honest, well done, independent study.

    View all comments by Gerardo Morfini

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