Noguchi-Shinohara M, Tokuda T, Yoshita M, Kasai T, Ono K, Nakagawa M, El-Agnaf OM, Yamada M. CSF alpha-synuclein levels in dementia with Lewy bodies and Alzheimer's disease. Brain Res. 2009 Jan 28;1251:1-6. PubMed.
AlzBiomarker Database
Meta-Analysis
- DLB vs AD : Aβ42 (CSF)
- DLB vs AD : tau-p181 (CSF)
- DLB vs AD : tau-total (CSF)
- DLB vs AD : α-synuclein (CSF)
Curated Study Data
| Biomarker (Source) |
Cohort (N) |
Measurement Mean ± SD |
Method; Assay Name; Manufacturer |
Diagnostic Criteria |
|---|---|---|---|---|
| Aβ42 (CSF) |
AD (21) |
341.2 ± 74.5 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| Aβ42 (CSF) |
DLB (16) |
432.3 ± 204.1 pg/mL |
ELISA; Innotest; Innogenetics |
McKeith et al., 1996 |
| tau-p181 (CSF) |
AD (21) |
88.9 ± 26.8 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-p181 (CSF) |
DLB (16) |
38.3 ± 9.1 pg/mL |
ELISA; Innotest; Innogenetics |
McKeith et al., 1996 |
| tau-total (CSF) |
AD (21) |
724.8 ± 296.7 pg/mL |
ELISA; Innotest; Innogenetics |
McKhann et al., 1984 |
| tau-total (CSF) |
DLB (16) |
218.5 ± 79.6 pg/mL |
ELISA; Innotest; Innogenetics |
McKeith et al., 1996 |
| α-synuclein (CSF) |
AD (21) |
49.3 ± 44.5 ng/mL |
ELISA; Other/Not Specified; In-house |
McKhann et al., 1984 |
| α-synuclein (CSF) |
DLB (16) |
44.7 ± 24.9 ng/mL |
ELISA; Other/Not Specified; In-house |
McKeith et al., 1996 |
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