Battaglia F, Wang HY, Ghilardi MF, Gashi E, Quartarone A, Friedman E, Nixon RA.
Cortical plasticity in Alzheimer's disease in humans and rodents.
Biol Psychiatry. 2007 Dec 15;62(12):1405-12.
PubMed.
It is nice to see new evidence in support of the concept of reduced neuronal plasticity in Alzheimer disease (Buell and Coleman, 1979; Coleman et al., 1992). Furthermore, this paper from the Nixon labs provides important evidence for a mechanism of this reduced plasticity.
References:
Buell SJ, Coleman PD.
Dendritic growth in the aged human brain and failure of growth in senile dementia.
Science. 1979 Nov 16;206(4420):854-6.
PubMed.
Coleman PD, Kazee AM, Lapham L, Eskin T, Rogers K.
Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease.
Neurobiol Aging. 1992 Nov-Dec;13(6):631-9.
PubMed.
Comments
Banner Research Institute
It is nice to see new evidence in support of the concept of reduced neuronal plasticity in Alzheimer disease (Buell and Coleman, 1979; Coleman et al., 1992). Furthermore, this paper from the Nixon labs provides important evidence for a mechanism of this reduced plasticity.
References:
Buell SJ, Coleman PD. Dendritic growth in the aged human brain and failure of growth in senile dementia. Science. 1979 Nov 16;206(4420):854-6. PubMed.
Coleman PD, Kazee AM, Lapham L, Eskin T, Rogers K. Reduced GAP-43 message levels are associated with increased neurofibrillary tangle density in the frontal association cortex (area 9) in Alzheimer's disease. Neurobiol Aging. 1992 Nov-Dec;13(6):631-9. PubMed.
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