Little JT, Johnson DN, Minichiello M, Weingartner H, Sunderland T.
Combined nicotinic and muscarinic blockade in elderly normal volunteers: cognitive, behavioral, and physiologic responses.
Neuropsychopharmacology. 1998 Jul;19(1):60-9.
PubMed.
The abstract suggests that the combined blockade produced may be a pharmacologic model of the memory deficits of AD. Whether this models a major mechanism of memory defect in AD depends on the relation of transmitter status to synaptic loss, hippocampal disconnection and cell death in AD.
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Banner Research Institute
The abstract suggests that the combined blockade produced may be a pharmacologic model of the memory deficits of AD. Whether this models a major mechanism of memory defect in AD depends on the relation of transmitter status to synaptic loss, hippocampal disconnection and cell death in AD.
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