Weninger S, Carrillo MC, Dunn B, Aisen PS, Bateman RJ, Kotz JD, Langbaum JB, Mills SL, Reiman EM, Sperling R, Santacruz AM, Tariot PN, Welsh-Bohmer KA. Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials. Alzheimers Dement. 2016 May;12(5):631-2. PubMed.

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  1. A perfect example for sharing biological samples is DIAN. This is exactly how biological samples from clinical cohorts should be made available to the research community with the goal of performing the best science. This is clearly in the interest of the participating patients and their families. The willingness to share such valuable materials may be exemplary for cohorts established in other countries including Germany.

    DIAN enabled us in Munich to obtain CSF samples from 127 well-characterized mutation carriers and 91 non-carrier siblings for an exciting study aimed at following microglial activation before disease onset and during disease progression. Sharing these samples not only allowed my lab to conduct a fascinating research project, but it also helped enormously to initiate true translational research in a group that had exclusively performed basic research for two decades.

    View all comments by Christian Haass

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  1. CAP Articulates Plan for Sharing Data from Trials of Preclinical Alzheimer’s Disease