Mesentier-Louro LA, Goldman C, Ndayisaba A, Buonfiglioli A, Rooklin RB, Schuldt BR, Uchitelev A, Khurana V, Blanchard JW. Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain Tissue. 2025 Feb 14 10.1101/2025.02.09.637107 (version 2) bioRxiv.

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Mutations

  1. APOE C130R (ApoE4)