Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan;70(1):210-5. PubMed.

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    • User Profile Image Hiroshi Mori
      Osaka City University Medical School
    • Posted:

    This is one of important studies to show the BBB transfer of amyloid peptide into brain tissue. Although the question remains whether the conformation of amyloid peptide is the same as in vivo, it is interesting for the blood-origin theorists.

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