Sulkava R, Viinikka L, Erkinjuntti T, Roine R. Cerebrospinal fluid neuron-specific enolase is decreased in multi-infarct dementia, but unchanged in Alzheimer's disease. J Neurol Neurosurg Psychiatry. 1988 Apr;51(4):549-51. PubMed.

AlzBiomarker Database

Meta-Analysis

Curated Study Data

Biomarker
(Source)		 Cohort
(N)		 Measurement
Mean ± SD		 Method;
Assay Name;
Manufacturer		 Diagnostic
Criteria
NSE
(CSF)		 AD
(22)		 9.1 ± 0.47†
ng/mL		 Radio Immunoassay;
Other/Not Specified;
Pharmacia Corp.		 McKhann et al., 1984
NSE
(CSF)		 CTRL-
Other Controls
(15)		 8.6 ± 0.67†
ng/mL		 Radio Immunoassay;
Other/Not Specified;
Pharmacia Corp.
NSE
(CSF)		 VaD
(35)		 6.5 ± 0.41†
ng/mL		 Radio Immunoassay;
Other/Not Specified;
Pharmacia Corp.		 1979

† Mean ± SEM

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AlzBiomarker

  1. AD vs CTRL : NSE (CSF)
  2. CTRL vs AD : NSE (CSF)
  3. VaD vs AD : NSE (CSF)