It is obscure whether apoptosis is involved in AD apthogenesis. Study of bcl-2 and p53 and other related molecules are interesting for understanding neuronal viability in AD brain.
In the abstract the authors comment that " No differences between Bcl-2 and Bax immunoreactivity in tangle-bearing and non-tangle-bearing neurons were observed, thus suggesting that Bcl-2 and Bax do not participate in tangle formation. " This comment is consistent with other data suggesting that NFT may not be necessary for neuron death in AD.
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Osaka City University Medical School
It is obscure whether apoptosis is involved in AD apthogenesis. Study of bcl-2 and p53 and other related molecules are interesting for understanding neuronal viability in AD brain.
Banner Research Institute
In the abstract the authors comment that " No differences between Bcl-2 and Bax immunoreactivity in tangle-bearing and non-tangle-bearing neurons were observed, thus suggesting that Bcl-2 and Bax do not participate in tangle formation. " This comment is consistent with other data suggesting that NFT may not be necessary for neuron death in AD.
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